Biologics Blog with Useful Links

During our daily work we come across a lot of information which might be useful for our customers and visitors from the biopharmaceutical industry. This blog will try to facilitate access to interesting data, reports and other information related to biologics, but not limited to. In addition, we will present our point of view and comment news in a fair, but succinct way. We hope you will enjoy our contributions and will appreciate any helpful comment and response from you.

STUTTGART, Germany I March 17, 2017 I Sales of branded originator biologics in 2016 continued to reach a record high of US$ 163 bln, a plus of 5.8% compared with the previous year. Growth drivers were therapeutic antibodies for treatment of cancer and inflammatory diseases, especially the emerging immuno-oncology antibodies and novel anti-inflammatory antibodies different from anti-TNF. Interestingly, sales of all anti-inflammatory antibodies including the anti-TNF family were 63% higher…
STUTTGART, Germany I January 25, 2017 I The acquisition of oncolytic virus company BioVex by Amgen in late 2011 for up to US$ 1 bln has been a game changer for the field of oncolytic viruses, now recognized as a promising new therapeutic approach for cancer treatment. The approval of Amgen‘s herpes simplex oncolytic virus Imlygic in late 2015 further strengthened this trend as evidenced by the fact that total…
STUTTGART, Germany I August 10, 2016 I Immunotherapy of B-cell malignancies with specifically targeted autologous T-cells most probably will see the first adoptive cell therapy products approved in the year 2017. Novartis, Kite Pharma and Juno Therapeutics are in a head-to-head race to be first on the market with anti-CD19 chimeric antigen receptor (CAR) T-cells. However, the success story with CD19 CAR T-cells is not as easily repeated with CAR…
STUTTGART, Germany I May 13, 2016 I Immunotherapy of cancer with direct or indirect use of T-cells is one of the most exciting fields in cancer research. Direct T-cell therapy implies the ex vivo engineering of autologous or allogeneic T-cells for tumor targeting by chimeric antigen receptors (CAR) or T-cell receptors (TCR). Despite stunning clinical results with CD19-targeted CAR T-cells, many major pharmaceutical companies have not embarked on adoptive cell…
STUTTGART, Germany I March 14, 2016 I 2015 was another year of record sales of recombinant therapeutic proteins and antibodies despite the beginning commercialization of biosimilar antibodies and proteins. Global sales of originator antibodies and proteins reached USD 154 bln, a growth of 9.2% compared with the previous year. While sales of anti-TNF antibodies slowed down, the strong growth was mainly due to antibodies (+11.3%) driven by sales of cancer…
STUTTGART, Germany I February 4, 2016 I Targeting the proinflammatory cytokine interleukin-17 (IL-17) produced by T helper cells has become a clinically validated strategy of successfully treating psoriasis, psoriatic arthritis and ankylosing spondylitis. The first approved and marketed antibody secukinumab from Novartis also shows great commercial promise as evidenced by sales of US$ 261 mln in the first year of market launch. The success is due to superior efficacy of…
STUTTGART, Germany I December 2, 2015 I Only a few years ago, before the times of immuno-oncology and chimeric antigen receptor (CAR) T-Cell Therapeutics, antibody-drug conjugates (ADC) were the most exciting investment opportunity in oncology which nobody wanted to miss. Since then, the exaggerated expectations have waned because the early successes with Kadcyla and Adcetris could not be repeated as quickly as investors had hoped. Antibody-drug conjugates as a class,…
By definition, rare disease are those disorders which affect less than 200,000 patients in the US. A new report lists the more than 450 compounds under development by US companies for treatment of rare diseases. The study was published by PhRMA, the Pharmaceutical Research and Manufacturers of America and can be downloaded at http://phrma.org/sites/default/files/pdf/Rare_Diseases_2013.pdf The range of rare diseases for which new drugs are being developing, is spanning from cancer…
October 24, 2013 I La Merie published in February 2007 for the first time a compilation of the annual sales of therapeutic proteins and antibodies. Since then, we released every year our list of TOP selling antibodies and proteins. You can find these annual reports published in our weekly newsletter R&D Pipeline News as a special edition in our online portal www.pipelinereview.com under FREE Reports. We thought you might find…
October 17, 2013 I Undoubtedly, antibodies are a hot area for biotech and pharma companies. Development of antibody therapeutics not only seems to have a lower attrition rate than that of small molecules (at least for toxicity reasons), but antibody products are extremely commercially successful. No wonder, that many companies are „jumping on the wagon" of antibodies. However, only a fraction of the companies is working on antibody molecules directed…
October 8, 2013 I The association of America’s biopharmaceutical companies (the Pharmaceutical Research and Manufacturers of America: PhRMA) recently released the report „Medicines in Development for Vaccines„. The report states that US companies are developing 271 vaccines in clinical stages to prevent or treat a variety of diseases including allergy, neurological diseases, cancer, infectious diseases and some others. The vast majority of vaccines is being developed for infections diseases (51%)…

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